Small RNAs-cell physiology, a dual analog of dose-response kinetics. (Christos Kotakis, 30 November 2011)

Currently, I read the interesting minireview by Grimm in Silence journal (doi:10.1186/1758-907X-2-8), concerning siRNAs¿ toxic effects in cell vitality as it was probed in vivo. According to this paper, it has been collectively reported in different works that the desirable effect of RNAi bioassays is dependent on the small RNAs¿ dosage. In other words, there are some limitations in the efficiency of small RNAs¿ action per se, due to a `saturating¿ plateau referring, not only to the RNA silencing mechanism sensitivity but also in the consequences of those universal `entities¿ on cellular... read full comment

Comment on: Grimm Silence, 2:8