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Open Access Highly Accessed Open Badges Review

Application of RNA silencing to plant disease resistance

Cheng-Guo Duan12, Chun-Han Wang1 and Hui-Shan Guo1*

Author Affiliations

1 State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China

2 Present address: Department of Horticulture & Landscape Architecture, Purdue University, West Lafayette, IN, 47906, USA

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Silence 2012, 3:5  doi:10.1186/1758-907X-3-5

Published: 31 May 2012


To reduce the losses caused by plant pathogens, plant biologists have adopted numerous methods to engineer resistant plants. Among them, RNA silencing-based resistance has been a powerful tool that has been used to engineer resistant crops during the last two decades. Based on this mechanism, diverse approaches were developed. In this review, we focus on the application of RNA silencing to produce plants that are resistant to plant viruses such as RNA and DNA viruses, viroids, insects, and the recent expansion to fungal pathogens.

RNA silencing; Resistance; Virus; Viroid; PTGS; TGS; HIGS