Table 2

PAR-CLIP data show that endogenous miRNA tend to target mRNAs with long 3' UTR

Very Long

Long

Med Long

Med Short

Short

AllRef

917

6194

6201

6198

6201

AGO1

787 (85.82%)

3757 (60.66%)

2371 (38.24%)

1123 (18.12%)

471 (7.60%)

AGO2

320 (34.90%)

1010 (16.31%)

428 (6.90%)

148 (2.39%)

64 (1.03%)

AGO3

883 (96.29%)

4800 (77.49%)

3332 (53.73%)

1804 (29.11%)

639 (10.30%)

AGO4

713 (77.75%)

3087 (49.84%)

1510 (24.35%)

639 (10.31%)

167 (2.69%)

The table shows the total number of genes (AllRef) and the number of Argonaute-bound 3' UTRs (AGO1-4) for each sub-group defined by 3' UTR length (see Methods). Values in brackets indicate the percentage of all genes in the sub-group that have AGO binding sites. miRNA, microRNA; mRNA, messenger RNA; PAR-CLIP, Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation; UTR, untranslated region.

Saito and Sætrom Silence 2012 3:3   doi:10.1186/1758-907X-3-3