Potential mechanisms through which chromatin regulator-RNA complexes target specific sites in the genome. A. Targeting through a sequence-specific DNA binding protein. B. Targeting through looping of the ncRNA locus to the site of activity. C. Targeting through direct RNA-DNA interaction, for example triplex formation. D. RNA as a mechanism to target regulatory proteins to sites of transcription.
Kanhere and Jenner Silence 2012 3:2 doi:10.1186/1758-907X-3-2