Silence


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Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation

Michael Johnston1 and Gyorgy Hutvagner2,3

Author Affiliations

1 RNA Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, LFW D18.1 Universitätstrasse 2, 8092, Zürich, Switzerland

2 Centre for Health Technologies, University of Technology Sydney, Sydney, NSW 2007, Australia

3 Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK

Silence 2011, 2:5 doi:10.1186/1758-907X-2-5

Published: 26 September 2011

Additional files

Additional file 1:

Table S1. Posttranslational modification conservation of site-specific residues on Argonautes involved in miRNA-mediated gene regulation. Tick represents residue that is fully conserved and predicted to be modified. Cross represents residue that is not conserved and therefore will not be modified. For posttranslational modifications where site-specific residue has yet to be determined, "Not tested" represents that there is insufficient evidence to suggest whether posttranslational modification is present, whereas tick indicates that the Argonaute has been experimentally shown to be modified.

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