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Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation

Michael Johnston1 and Gyorgy Hutvagner23

Author Affiliations

1 RNA Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, LFW D18.1 Universitätstrasse 2, 8092, Zürich, Switzerland

2 Centre for Health Technologies, University of Technology Sydney, Sydney, NSW 2007, Australia

3 Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK

Silence 2011, 2:5  doi:10.1186/1758-907X-2-5

Published: 26 September 2011


Shortly after their discovery, repertoires of miRNA were identified, together with proteins involved in their biogenesis and action. It is now obvious that miRNA-mediated gene regulation itself is regulated at multiple levels. Identifying the regulatory mechanisms that underpin small RNA homeostasis by modulation of their biogenesis and action has become a key issue, which can be partly resolved by identifying mediators of Argonautes turnover. An emerging theme in the control of Argonaute stability and activity is through posttranslational modifications, which are the focus of this review.

posttranslational modifications; phosphorylation; ubiquitination; Argonautes; miRNA; RNAi