Research
Specificity and functionality of microRNA inhibitors
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* Corresponding author: Annaleen Vermeulen annaleen.vermeulen@thermofisher.com
1 Dharmacon Products, Thermo Fisher Scientific, 2650 Crescent Drive, Suite 100 Lafayette, CO 80026, USA
2 Department of Chemistry and Biochemistry, University of Colorado at Boulder, UCB 215, Boulder, CO 80309, USA
3 RXi Pharmaceuticals, 60 Prescott Street, Worcester, MA 01605, USA
Silence 2010, 1:10 doi:10.1186/1758-907X-1-10
Published: 1 April 2010Additional files
Additional file 1:
Supplemental Figures and Tables. Supplemental Figure S1 - All let-7 family member reporter assays show crossreactivity between all let-7 inhibitors, although the degree of apparent crossreactivity varies across reporters. Supplemental Figure S2 - Dose curves of fully complementary inhibitors co-transfected with cognate reporters. Supplemental Table S1 - Sequences of let-7 inhibitor target sites. Supplemental Table S2 - Sequences of mismatched inhibitor target sites.
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