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Methods   Open Access

cWords - systematic microRNA regulatory motif discovery from mRNA expression data

Simon H Rasmussen, Anders Jacobsen, Anders Krogh Silence 2013, 4:2 (20 May 2013)

Abstract | Full text | PDF | PubMed

Methods   Open Access

Generation of a luciferase-based reporter for CHH and CG DNA methylation in Arabidopsis thaliana

Thanh Theresa Dinh, Michael O’Leary, So Youn Won, Shengben Li, Lorena Arroyo, Xigang Liu, Andrew Defries, Binglian Zheng, Sean R Cutler, Xuemei Chen Silence 2013, 4:1 (5 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

Methods   Open Access

Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection

Zhao Zhang, William E Theurkauf, Zhiping Weng, Phillip D Zamore Silence 2012, 3:9 (28 December 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access

MicroRNAs from the same precursor have different targeting properties

Antonio Marco, Jamie I MacPherson, Matthew Ronshaugen, Sam Griffiths-Jones Silence 2012, 3:8 (27 September 2012)

Abstract | Full text | PDF | PubMed

Editorial   Open Access

RNA: methods and protocols — a new series

Phillip D Zamore Silence 2012, 3:7 (7 June 2012)

Abstract | Full text | PDF | PubMed

Methods   Open Access

Development of a luciferase-based reporter of transcriptional gene silencing that enables bidirectional mutant screening in Arabidopsis thaliana

So Youn Won, Shengben Li, Binglian Zheng, Yuanyuan Zhao, Dongming Li, Xin Zhao, Huilan Yi, Lei Gao, Thanh Theresa Dinh, Xuemei Chen Silence 2012, 3:6 (7 June 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A luciferase-based reporter system, LUCH, is used to screen for bidirectional mutants that enhance or suppress transcriptional gene silencing, elucidating the mechanisms of DNA methylation and demethylation.

Review   Open Access

Application of RNA silencing to plant disease resistance

Cheng-Guo Duan, Chun-Han Wang, Hui-Shan Guo Silence 2012, 3:5 (31 May 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Hui-Shan Guo and colleagues review the application of RNA silencing in engineering plants that are resistant to plant viruses, viroids, insects and, more recently, fungal pathogens.

Short report   Open Access

Reducing ligation bias of small RNAs in libraries for next generation sequencing

Karim Sorefan, Helio Pais, Adam E Hall, Ana Kozomara, Sam Griffiths-Jones, Vincent Moulton, Tamas Dalmay Silence 2012, 3:4 (30 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access

Target gene expression levels and competition between transfected and endogenous microRNAs are strong confounding factors in microRNA high-throughput experiments

Takaya Saito, Pål Sætrom Silence 2012, 3:3 (10 February 2012)

Abstract | Full text | PDF | PubMed

Minireview   Open Access

Noncoding RNA localisation mechanisms in chromatin regulation

Aditi Kanhere, Richard G Jenner Silence 2012, 3:2 (31 January 2012)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Inhibition of microRNA function by antimiR oligonucleotides

Jan Stenvang, Andreas Petri, Morten Lindow, Susanna Obad, Sakari Kauppinen Silence 2012, 3:1 (9 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Minireview   Open Access

The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression

Dirk Grimm Silence 2011, 2:8 (26 October 2011)

Abstract | Full text | PDF | PubMed | 1 comment

Research   Open Access

Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression

Cédric Belair, Jessica Baud, Sandrine Chabas, Cynthia M Sharma, Jörg Vogel, Cathy Staedel, Fabien Darfeuille Silence 2011, 2:7 (25 October 2011)

Abstract | Full text | PDF | PubMed

Meeting report   Open Access

Noncoding RNAs and cancer

Ohad Yogev, Dimitris Lagos Silence 2011, 2:6 (29 September 2011)

Abstract | Full text | PDF | PubMed

Minireview   Open Access

Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation

Michael Johnston, Gyorgy Hutvagner Silence 2011, 2:5 (26 September 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

A 5′-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation

Hervé Seitz, Jogender S Tushir, Phillip D Zamore Silence 2011, 2:4 (7 June 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

Nikolaus Schultz, Dina R Marenstein, Dino A De Angelis, Wei-Qing Wang, Sven Nelander, Anders Jacobsen, Debora S Marks, Joan Massagué, Chris Sander Silence 2011, 2:3 (14 March 2011)

Abstract | Full text | PDF | PubMed

Review   Open Access

Experimental design, preprocessing, normalization and differential expression analysis of small RNA sequencing experiments

Kevin P McCormick, Matthew R Willmann, Blake C Meyers Silence 2011, 2:2 (28 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access

Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors

John C Schmitz, Edward Chu Silence 2011, 2:1 (19 January 2011)

Abstract | Full text | PDF | PubMed

Research   Open Access

MicroR159 regulation of most conserved targets in Arabidopsis has negligible phenotypic effects

Robert S Allen, Junyan Li, Maria M Alonso-Peral, Rosemary G White, Frank Gubler, Anthony A Millar Silence 2010, 1:18 (28 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research   Open Access

A structural-based statistical approach suggests a cooperative activity of PUM1 and miR-410 in human 3'-untranslated regions

Limor Leibovich, Yael Mandel-Gutfreund, Zohar Yakhini Silence 2010, 1:17 (22 September 2010)

Abstract | Full text | PDF | PubMed

Methodology   Open Access

In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR)

Yosef Landesman, Nenad Svrzikapa, Armand Cognetta, Xuemei Zhang, Brian R Bettencourt, Satya Kuchimanchi, Keri Dufault, Sarfraz Shaikh, Maple Gioia, Akin Akinc, Renta Hutabarat, Rachel Meyers Silence 2010, 1:16 (23 August 2010)

Abstract | Full text | PDF | PubMed

Research   Open Access

An endogenous F-box protein regulates ARGONAUTE1 in Arabidopsis thaliana

K Earley, MR Smith, R Weber, BD Gregory, RS Poethig Silence 2010, 1:15 (12 July 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

An endogenous F-box protein negatively regulates the protein levels of ARGONAUTE1, a core component of the RNA-induced silencing complex, and affects the sensitivity of plants to the growth regulator abscisic acid.

Review   Open Access Highly Accessed

A status report on RNAi therapeutics

Akshay K Vaishnaw, Jared Gollob, Christina Gamba-Vitalo, Renta Hutabarat, Dinah Sah, Rachel Meyers, Tony de Fougerolles, John Maraganore Silence 2010, 1:14 (8 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Meeting report   Open Access

RNA silencing in plants: Flash report!

Rebecca A Mosher, Mathew G Lewsey, Padubidri V Shivaprasad Silence 2010, 1:13 (30 June 2010)

Abstract | Full text | PDF | PubMed

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